Longévité et pleine santé : les secrets dévoilés des meilleurs ingrédients naturels

Description

Notre vieillissement est certes inéluctable, mais peut-on le freiner substantiellement ? S'il apparaît difficile au cours de sa vie d'échapper aux maladies dites de civilisation (diabète, obésité, cancers, maladies cardiovasculaires, etc.), peut-on s'en protéger efficacement ? La réponse est deux fois oui.

Car la science a identifié à la fois les processus biologiques dégénératifs en cause et les solutions naturelles les plus puissantes pour les contrôler. Un livre référence pour une approche holistique et écologique de la Santé.

Détails produit

• Broché: 162 pages
• Editeur : MARIE CLAIRE ÉDITIONS (16/03/2021)
• Langue : Français
• ISBN-13: 979-10-323-0578-2
• Dimensions du produit: 16,9 cm × 22,9 cm × 1,2 cm

Bibliographie

SYLIMARINE

Oxydation, inflammation et glycation 

- Reina M, Martínez A. Is Silybin the Best Free Radical Scavenger Compound in Silymarin? J Phys Chem B. 2016 May 26; 120(20):4568-78.

- Arafa Keshk W, Zahran SM, Katary MA, Abd-Elaziz Ali D. Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer. Chem Biol Interact. 2017 Aug 1; 273:266-272.

- Serviddio G, Bellanti F, Stanca E, Lunetti P, Blonda M, Tamborra R, Siculella L, Vendemiale G, Capobianco L, Giudetti AM. Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliarycirrhosis. Free Radic Biol Med. 2014 Aug; 73:117-26.

- Feng B, Meng R, Huang B, Shen S, Bi Y, Zhu D. Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice. Free Radic Res. 2016;50(3):314-27.

- Shin S, Lee JA, Kim M, Kum H, Jung E, Park D. Anti-glycation activities of phenolic constituents from Silybum marianum (Milk Thistle) flower in vitro and on human explants. Molecules. 2015 Feb 19;20(3):3549-64.

- Neelofar K, Arif Z, Ahmad J, Alam K. Inhibitory effect of silibinin on Amadori-albumin in diabetes mellitus: A multi-spectroscopic and biochemical approach. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Feb 15 ;209 :217-222.

- Gabrielová E, Jabůrek M, Gažák R, et al. Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism. J Bioenerg Biomembr. 2010 ;42(6) :499‐509.

Activités hépatoprotectrices, cardioprotectrices, neuroprotectrices, anti-inflammatoires et anti-cancérogène. Cytoprotection contre les agents toxiques chimiques et biologiques

- Fanoudi S, Alavi MS, Karimi G, Hosseinzadeh H. Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol. 2018 Jul 22:1-15.

- Zaulet M, Kevorkian SEM, Dinescu S, Cotoraci C, Suciu M, Herman H, Buburuzan L, Badulescu L, Ardelean A, Hermenean A. Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver. Exp Ther Med. 2017 Mar;13(3):821-828.

- Milić N, Milosević N, Suvajdzić L, Zarkov M, Abenavoli L. New therapeutic potentials of milk thistle (Silybum marianum). Nat Prod Commun. 2013Dec ;8(12):1801-10. Review.

- de Souza Santos V, Peters B, Côco LZ, Alves GM, de Assis ALEM, Nogueira BV,Meyrelles SS, Porto ML, Vasquez EC, Campagnaro BP, Pereira TMC. Silymarin protects against radiocontrast-induced nephropathy in mice. Life Sci. 2019 Apr 29. pii: S0024-3205(19)30329-7.

- Kim S, Han J, Jeon M, You D, Lee J, Kim HJ, Bae S, Nam SJ, Lee JE. Silibinin inhibits triple negative breast cancer cell motility by suppressing TGF-β2 expression. Tumour Biol. 2016 Aug;37(8):11397-407.

- Amiri M, Motamedi P, Vakili L, Dehghani N, Kiani F, Taheri Z, Torkamaneh S,Nasri P, Nasri H. Beyond the liver protective efficacy of silymarin; bright renoprotective effect on diabetic kidney disease. J Nephropharmacol. 2014 Jul 1;3(2):25-26.

- Wu JP, Tsai CC, Yeh YL, Lin YM, Lin CC, Day CH, Shen CY, Padma VV, Pan LF, Huang CY. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evid Based Complement Alternat Med. 2015; 2015:603529. doi: 10.1155/2015/603529.Epub 2015 Aug 3. Retraction in: Evid Based Complement Alternat Med. 2017; 2017:2575273.

- Gillessen A, Herrmann WA, Kemper M, Morath H, Mann K. [Effect of silymarin on liver health and quality of life. Results of a non-interventional study]. MMW Fortschr Med. 2014 Dec 15;156 Suppl 4:120-6.

- Yaghmaei P, Azarfar K, Dezfulian M, Ebrahim-Habibi A. Silymarin effect onamyloid-β plaque accumulation and gene expression of APP in an Alzheimer's disease rat model. Daru. 2014 Jan 24;22(1):24.

- Fatehi D, Mohammadi M, Shekarchi B, Shabani A, Seify M, Rostamzadeh A. Radioprotective effects of Silymarin on the sperm parameters of NMRI mice irradiated with γ-rays. J Photochem Photobiol B. 2018 Jan; 178:489-495.

- Elyasi S, Hosseini S, Niazi Moghadam MR, Aledavood SA, Karimi G. Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Phytother Res.2016 Nov;30(11):1879-1885.

Syndrome métabolique et diabète

- Wat E, Wang Y, Chan K, Law HW, Koon CM, Lau KM, Leung PC, Yan C, Lau CBS. An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome. Phytomedicine. 2018 Mar 15; 42:112-125.

- Vahabzadeh M, Amiri N, Karimi G. Effects of silymarin on metabolic syndrome: a review. J Sci Food Agric. 2018 Oct;98(13):4816-4823. doi: 10.1002/jsfa.9115. Epub 2018 Jun 27. Review.

- Tajmohammadi A, Razavi BM, Hosseinzadeh H. Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review. Phytother Res. 2018 Oct;32(10):1933-1949. doi:10.1002/ptr.6153. Epub 2018 Jul 17. Review.

- Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother Res. 2006 Dec;20(12):1036-9.

- Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin)extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018 May 15; 44:39-44.

- Hadi A, Pourmasoumi M, Mohammadi H, Symonds M, Miraghajani M. The effects of silymarin supplementation on metabolic status and oxidative stress in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials. Complement Ther Med. 2018 Dec; 41:311-319.

BERBÉRINE

Inflammation, oxydation et glycation

- Li CL, Tan LH, Wang YF, Luo CD, Chen HB, Lu Q, Li YC, Yang XB, Chen JN, Liu YH, Xie JH, Su ZR. Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo. Phytomedicine. 2019 Jan; 52:272-283.

- Li X, He P, Hou Y, Chen S, Xiao Z, Zhan J, Luo D, Gu M, Lin D. Berberine inhibits the interleukin-1 beta-induced inflammatory response via MAPK downregulation in rat articular chondrocytes.

- Liang Y, Fan C, Yan X, Lu X, Jiang H, Di S, Ma Z, Feng Y, Zhang Z, Feng P, Feng X, Feng J, Jin F. Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis. Phytother Res. 2019 Jan;33(1):130-148.

- Eissa LA, Kenawy HI, El-Karef A, Elsherbiny NM, El-Mihi KA. Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats. Chem Biol Interact. 2018 Oct 1;294:91-100.

- Kassab RB, Vasicek O, Ciz M, Lojek A, Perecko T. The effects of berberine on reactive oxygen species production in human neutrophils and in cell-free assays. Interdiscip Toxicol. 2017 Oct;10(2):61-65.

- Bai M, Liu Y, Zhou F, Zhang Y, Zhu Q, Zhang L, Zhang Q, Wang S, Zhu K, Wang X,Zhou L. Berberine inhibits glucose oxidation and insulin secretion in rat islets.Endocr J. 2018 Apr 26;65(4):469-477.

- Hao M, Li SY, Sun CK, Jingyu-Xu, Lin Y, Liu KX, Wang L, Li CX, Zhou Q, Du JL, Li H. Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro. Eur J Pharmacol. 2011 Mar 11;654(3):320-5.

- Qiu YY, Tang LQ, Wei W. Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy.Mol Cell Endocrinol. 2017 Mar 5; 443:89-105.

- Mo C, Wang L, Zhang J, Numazawa S, Tang H, Tang X, Han X, Li J, Yang M, WangZ, Wei D, Xiao H. The crosstalk between Nrf2 and AMPK signal pathways isimportant for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice. Antioxid Redox Signal. 2014 Feb 1;20(4):574-88.

- Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, Chen Z, Shioda S, Guo Y. Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation. Aging Dis. 2017 Dec 1;8(6):760-777.

Protection maladies cardiovasculaires (HTA...) et métaboliques (diabète, hyperlipidémie, glycation...)

- Feng X, Sureda A, Jafari S, Memariani Z, Tewari D, Annunziata G, Barrea L,Hassan STS, Šmejkal K, Malaník M, Sychrová A, Barreca D, Ziberna L, Mahomoodally MF, Zengin G, Xu S, Nabavi SM, Shen AZ. Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics. Theranostics. 2019 Mar16;9(7):1923-1951. doi: 10.7150/thno.30787. eCollection 2019. Review.

- Liang Y, Xu X, Yin M, Zhang Y, Huang L, Chen R, Ni J. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J. 2019 Jan 28;66(1):51-63.

- Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J, Sun G. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus,hyperlipemia and hypertension. J Ethnopharmacol. 2015 Feb 23;161:69-81.

- Koppen LM, Whitaker A, Rosene A, Beckett RD. Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review. J Evid Based Complementary Altern Med. 2017 Oct;22(4):956-968.

- Dong H, Zhao Y, Zhao L, Lu F. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med.2013 Apr;79(6):437-46. doi: 10.1055/s-0032-1328321. Epub 2013 Mar 19. Review.

- Cicero AF, Baggioni A. Berberine and Its Role in Chronic Disease. Adv Exp Med Biol. 2016;928:27-45. Review.

- Caliceti C, Franco P, Spinozzi S, Roda A, Cicero AF. Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders. Curr Med Chem. 2016;23(14):1460-76. Review.

- Chang W, Chen L, Hatch GM. Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies. Biochem Cell Biol.2015 Oct;93(5):479-86. doi: 10.1139/bcb-2014-0107. Epub 2014 Dec 1. Review.

- Derosa G, Maffioli P, Cicero AF. Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials. Expert Opin Biol Ther. 2012 Aug;12(8):1113-24.

- Pirillo A, Catapano AL. Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.

- Atherosclerosis. 2015 Dec;243(2):449-61. doi: 10.1016/j.atherosclerosis.2015.09.032. Epub 2015 Sep 30. Review.

- Memon MA, Khan RN, Riaz S, Ain QU, Ahmed M, Kumar N. Methylglyoxal and insulin resistance in berberine-treated type 2 diabetic patients. J Res Med Sci. 2018 Dec 28;23:110. doi: 10.4103/jrms.JRMS_1078_17. eCollection 2018. Erratum in: J Res Med Sci. 2019 Apr 02;24:28.

- Almani SA, Memon IA, Shaikh TZ, Khoharo HK, Ujjan I. Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus. Iran J Basic Med Sci. 2017 May;20(5):511-515.

- Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P. Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7777-85.

- Ma H, He K, Zhu J, Li X, Ye X. The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine. Fitoterapia. 2019 Apr;134:210-220.

- Shao YJ, Tao J, Yu BB, Meng D, Yang XL, Sun JP, Qiu YX, Zhang XY. Berberine-Promoted CXCR4 Expression Accelerates Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Persons with Prehypertension. Chin J Integr Med. 2018 Dec;24(12):897-904.

- Yu Y, Zhang M, Hu Y, Zhao Y, Teng F, Lv X, Li J, Zhang Y, Hatch GM, Chen L.Increased Bioavailable Berberine Protects Against Myocardial Ischemia Reperfusion Injury Through Attenuation of NFκB and JNK Signaling Pathways. Int Heart J. 2018 Nov 28;59(6):1378-1388.

- Poudel A, Zhou J, Mekala N, Welchko R, Rosca M, Li L. Berberine protects against cytokine-induced inflammation through multiple pathways inundifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol. 2019 Apr 26.

 Neuro protection (récupération post-AVC, pathologies neuro dégénératives…)

- Zhu J, Cao D, Guo C, Liu M, Tao Y, Zhou J, Wang F, Zhao Y, Wei J, Zhang Y, Fang W, Li Y. Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling. Cell Mol Neurobiol. 2019 Apr 24.

- Fan D, Liu L, Wu Z, Cao M. Combating neurodegenerative diseases with the plantalkaloid berberine: molecular mechanisms and therapeutic potential. CurrNeuropharmacol. 2018 Apr 19.

- Ahmed T, Gilani AU, Abdollahi M, Daglia M, Nabavi SF, Nabavi SM. Berberine and neurodegeneration: A review of literature. Pharmacol Rep. 2015 Oct;67(5): 970-9.doi: 10.1016/j.pharep.2015.03.002.

- Kulkarni SK, Dhir A. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res. 2010 Mar;24(3):317-24.

- Chu M, Chen X, Wang J, Guo L, Wang Q, Gao Z, Kang J, Zhang M, Feng J, Guo Q, Li B, Zhang C, Guo X, Chu Z, Wang Y. Polypharmacology of Berberine Based on Multi-Target Binding Motifs. Front Pharmacol. 2018 Jul 24;9:801.

- Chu M, Chen X, Wang J, Guo L, Wang Q, Gao Z, Kang J, Zhang M, Feng J, Guo Q,Li B, Zhang C, Guo X, Chu Z, Wang Y. Polypharmacology of Berberine Based on Multi-Target Binding Motifs. Front Pharmacol. 2018 Jul 24;9:801.

- Huang SX, Qiu G, Cheng FR, Pei Z, Yang Z, Deng XH, Zhu JH, Chen L, Chen CC, Lin WF, Liu Y, Liu Z, Zhu FQ. Berberine Protects Secondary Injury in Mice with Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory Modulation. Neurochem Res. 2018 Sep;43(9):1814-1825.-Wang J, Zhang Y. Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via Sirt1/p38 MAPK expression. Mol Med Rep. 2018 May;17(5):6881-6886.

-Yu Y, Zhao Y, Teng F, Li J, Guan Y, Xu J, Lv X, Guan F, Zhang M, Chen L. Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. J Nutr Health Aging. 2018;22(6):710-717.

- Fan J, Zhang K, Jin Y, Li B, Gao S, Zhu J, Cui R. Pharmacological effects of berberine on mood disorders. J Cell Mol Med. 2019 Jan;23(1):21-28. doi: 10.1111/jcmm.13930. Epub 2018 Nov 18. Review.   

Protection cancer (sein, foie, côlon, LLA, pancréas...)

- Farooqi AA, Qureshi MZ, Khalid S, Attar R, Martinelli C, Sabitaliyevich UY,Nurmurzayevich SB, Taverna S, Poltronieri P, Xu B. Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy. Cancers (Basel). 2019 Apr 4;11(4). pii: E478. doi: 10.3390/cancers11040478. Review.

- Jabbarzadeh Kaboli P, Rahmat A, Ismail P, Ling KH. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer. Eur J Pharmacol. 2014 Oct 5; 740:584-95. doi: 10.1016/j.ejphar.2014.06.025. Epub 2014 Jun 26. Review.

- Wu K, Yang Q, Mu Y, Zhou L, Liu Y, Zhou Q, He B. Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. Int J Oncol. 2012 Jul;41(1):292-8. doi: 10.3892/ijo.2012.1423.

- Albring KF, Weidemüller J, Mittag S, Weiske J, Friedrich K, Geroni MC,Lombardi P, Huber O. Berberine acts as a natural inhibitor of Wnt/β-catenin signaling--identification of more active 13-arylalkyl derivatives. Biofactors.2013 Nov-Dec;39(6):652-62.

- Ortiz LM, Lombardi P, Tillhon M, Scovassi AI. Berberine, an epiphany againstcancer. Molecules. 2014 Aug 15;19(8):12349-67. doi: 10.3390/molecules190812349.Review. 

- Diogo CV, Machado NG, Barbosa IA, Serafim TL, Burgeiro A, Oliveira PJ. Berberine as a promising safe anti-cancer agent - is there a role for mitochondria? Curr Drug Targets. 2011 Jun;12(6):850-9. Review.

- Dai B, Ma Y, Yang T, Fan M, Yu R, Su Q, Wang H, Liu F, Yang C, Zhang Y. Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma.Phytother Res. 2019 Mar;33(3):745-755.

- Hu S, Chen CW, Chen ST, Tsui KH, Tang TK, Cheng HT, Hwang GS, Yu JW, Li YC,Wang PS, Wang SW. Inhibitory effect of berberine on interleukin-2 secretion from PHA-treated lymphocytic Jurkat cells. Int Immunopharmacol. 2019 Jan;66:267-273.

- Kim S, You D, Jeong Y, Yu J, Kim SW, Nam SJ, Lee JE. Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells. Phytomedicine. 2018 Nov 15;50:43-49.

- Abrams SL, Follo MY, Steelman LS, Lertpiriyapong K, Cocco L, Ratti S, Martelli AM, Candido S, Libra M, Murata RM, Rosalen PL, Montalto G, Cervello M, Gizak A,Rakus D, Mao W, Lombardi P, McCubrey JA. Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells. Adv Biol Regul. 2019 Jan;71:172-182.

- Zhao Y, Jing Z, Li Y, Mao W. Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis. Oncol Rep. 2016 Jul;36(1):567-72.

- Jabbarzadeh Kaboli P, Leong MP, Ismail P, Ling KH. Antitumor effects of berberine against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 breast cancer cells using molecular modelling and in vitro study. Pharmacol Rep. 2019 Feb;71(1):13-23.

-Yao Z, Wan Y, Li B, Zhai C, Yao F, Kang Y, Liu Q, Lin D. Berberine induces mitochondrial‑mediated apoptosis and protective autophagy in human malignant pleural mesothelioma NCI‑H2452 cells. Oncol Rep. 2018 Dec;40(6):3603-3610.

- Agnarelli A, Natali M, Garcia-Gil M, Pesi R, Tozzi MG, Ippolito C, Bernardini N, Vignali R, Batistoni R, Bianucci AM, Marracci S. Cell-specific pattern of berberine pleiotropic effects on different human cell lines. Sci Rep. 2018 Jul 13;8(1):10599.

- Li L, Wang X, Sharvan R, Gao J, Qu S. Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways. Biomed Pharmacother. 2017 Nov; 95:1225-1231.

Protection rétinienne, rénale et hépatique

- Li S, Gaur U, Chong CM, Lin S, Fang J, Zeng Z, Wang H, Zheng W. Berberine Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of AMPK. Int J Mol Sci. 2018 Jun 12;19(6).

- Kumaş M, Eşrefoğlu M, Karataş E, Duymaç N, Kanbay S, Ergün IS, Üyüklü M, Koçyiğit A. Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats. Nefrologia. 2019 Jan 31. pii: S0211-6995(19)30004-9.

- Hung TC, Jassey A, Liu CH, Lin CJ, Lin CC, Wong SH, Wang JY, Yen MH, Lin LT. Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein. Phytomedicine. 2019 Feb; 53:62-69.

- Sun H, Liu Q, Hu H, Jiang Y, Shao W, Wang Q, Jiang Z, Gu A. Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis. Cell Death Dis. 2018 Aug 1;9(8):824.

- Gholampour F, Keikha S. Berberine protects the liver and kidney against functional disorders and histological damages induced by ferrous sulfate. Iran J Basic Med Sci. 2018 May;21(5):476-482.

- Adil M, Kandhare AD, Dalvi G, Ghosh P, Venkata S, Raygude KS, Bodhankar SL.Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Ren Fail. 2016 Jul;38(6):996-1006.

- Lin Y, Sheng M, Ding Y, Zhang N, Song Y, Du H, Lu N, Yu W. Berberine protects renal tubular cells against hypoxia/reoxygenation injury via the Sirt1/p53pathway. J Nat Med. 2018 Jun;72(3):715-723.

- Ni WJ, Ding HH, Tang LQ. Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms. Eur J Pharmacol. 2015 Aug 5;760:103-12.

- Wu D, Wen W, Qi CL, Zhao RX, Lü JH, Zhong CY, Chen YY. Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin. Phytomedicine. 2012 Jun 15;19(8-9):712-8.

CURCUMINE

Inflammation, oxydation et glycation

- Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB, Rahimi M, Mobini M, Jafarnejad S, Vahedpoor Z, Asemi Z. The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019 Feb;33(2):253-262. doi: 10.1002/ptr.6226. Epub 2018 Nov 7. Review.

- Edwards RL, Luis PB, Varuzza PV, Joseph AI, Presley SH, Chaturvedi R,Schneider C. The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites. J Biol Chem. 2017 Dec 29;292(52):21243-21252.

- Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin inducesglutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid Redox Signal. 2005 Jan-Feb ;7(1-2):32-41.

- Joseph AI, Edwards RL, Luis PB, Presley SH, Porter NA, Schneider C. Stability and anti-inflammatory activity of the reduction resistant curcumin analog,2,6-dimethyl-curcumin. Org Biomol Chem. 2018 May 2;16(17):3273-3281.

- Kunwar A, Barik A, Sandur SK, Indira Priyadarsini K. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin. Free Radic Res. 2011 Aug;45(8):959-65.

- He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules. 2015 May 20 ;20(5): 9183-213.doi: 10.3390/molecules20059183. Review.

- Yuan J, Botchway BOA, Zhang Y, Tan X, Wang X, Liu X. Curcumin Can Improve Spinal Cord Injury by Inhibiting TGF-β-SOX9 Signaling Pathway. Cell Mol Neurobiol. 2019 Mar 26.

- Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.Int Immunopharmacol. 2012 Feb;12(2):368-77.

- Yamagishi SI, Matsui T, Ishibashi Y, Isami F, Abe Y, Sakaguchi T, Higashimoto Y. Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System. Curr Pharm Des. 2017;23(8):1135-1141.

- Alizadeh M, Kheirouri S. Curcumin against advanced glycation end products (AGEs) and AGEs-induced detrimental agents. Crit Rev Food Sci Nutr. 2017 Nov 29:1-9.

- Sun YP, Gu JF, Tan XB, Wang CF, Jia XB, Feng L, Liu JP. Curcumin inhibits advanced glycation end product-induced oxidative stress and inflammatory responses in endothelial cell damage via trapping methylglyoxal. Mol Med Rep.2016 Feb;13(2):1475-86.

- Sowndhar Rajan B, Manivasagam S, Dhanusu S, Chandrasekar N, Krishna K, Kalaiarasu LP, Babu AA, Vellaichamy E. Diet with high content of advanced glycation end products induces systemic inflammation and weight gain in experimental mice: Protective role of curcumin and gallic acid. Food Chem Toxicol. 2018 Apr; 114:237-245.

- Cheng K, Yang A, Hu X, Zhu D, Liu K. Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide Induced Acute Lung Injury in Neonatal Rat Model by Activating Peroxisome Proliferator-Activated Receptor γ (PPARγ) Pathway.Med Sci Monit. 2018 Feb 26; 24:1178-1184. 

- Wei Y, Gao J, Qin L, Xu Y, Shi H, Qu L, Liu Y, Xu T, Liu T. Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy. Exp Ther Med. 2017 Dec;14(6):6052-6058.

- Mofidi Najjar F, Taghavi F, Ghadari R, Sheibani N, Moosavi-Movahedi AA. Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin. Arch Biochem Biophys. 2017 Sep 15; 630:81-90.

- Tang Y, Chen A. Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling. Lab Invest. 2014 May;94(5):503-16.

- Yang Q, Wu S, Mao X, Wang W, Tai H. Inhibition effect of curcumin on TNF-α and MMP-13 expression induced by advanced glycation end products in chondrocytes. Pharmacology. 2013;91(1-2):77-85.

- Liu JP, Feng L, Zhu MM, Wang RS, Zhang MH, Hu SY, Jia XB, Wu JJ. The in vitro protective effects of curcumin and demethoxycurcumin in Curcuma longa extract on advanced glycation end products-induced mesangial cell apoptosis and oxidative stress. Planta Med. 2012 Nov;78(16):1757-60.

- Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013 Sep;57(9):1529-42. 

Protection cérébrale, hépatique, rénale, cardiaque, contre toxiques

- Wang XS, Zhang ZR, Zhang MM, Sun MX, Wang WW, Xie CL. Neuroprotective properties of curcumin in toxin-base animal models of Parkinson's disease: a systematic experiment literatures review. BMC Complement Altern Med. 2017 Aug 17;17(1):412.

 -Ramkumar M, Rajasankar S, Gobi VV, Dhanalakshmi C, Manivasagam T, Justin Thenmozhi A, Essa MM, Kalandar A, Chidambaram R. Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone inducedneurotoxicity in SH-SY 5Y Neuroblastoma cells. BMC Complement Altern Med. 2017 Apr 18;17(1):217.

- Nery-Flores SD, Mendoza-Magaña ML, Ramírez-Herrera MA, Ramírez-Vázquez JJ, Romero-Prado MMJ, Cortez-Álvarez CR, Ramírez-Mendoza AA. Curcumin Exerted Neuroprotection against Ozone-Induced Oxidative Damage and Decreased NF-κB

- Activation in Rat Hippocampus and Serum Levels of Inflammatory Cytokines. Oxid Med Cell Longev. 2018 Dec 30; 2018:9620684.

- Abrahams S, Haylett WL, Johnson G, Carr JA, Bardien S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress:A review. Neuroscience. 2019 Feb 28; 406:1-21.

- Krishnamoorthy A, Tavoosi N, Chan GKL, Liu J, Ren G, Cavigiolio G, Ryan RO.Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I. FEBS Open Bio. 2018 Jan 10;8(2):302-310.

- Benzer F, Kandemir FM, Kucukler S, Comaklı S, Caglayan C. Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: by modulating inflammatory cytokines, apoptosis, oxidative stress and oxidative DNA damage. Arch Physiol Biochem. 2018 Dec;124(5):448-457.

- Topcu-Tarladacalisir Y, Sapmaz-Metin M, Karaca T. Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis. Ren Fail. 2016 Nov;38(10):1741-1748.

- Benzer F, Kandemir FM, Ozkaraca M, Kucukler S, Caglayan C. Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogationof inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats. J Biochem Mol Toxicol. 2018 Feb;32(2).

- Shi LY, Zhang L, Li H, Liu TL, Lai JC, Wu ZB, Qin J. Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Pharmacol Rep. 2018 Oct;70(5):1040-1046.

- Shi LY, Zhang L, Li H, Liu TL, Lai JC, Wu ZB, Qin J. Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Pharmacol Rep. 2018 Oct;70(5):1040-1046.

- Bukhari SN, Jantan I. Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer’s Disease. Mini Rev Med Chem. 2015;15(13):1110-21. Review.

- Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One. 2012;7(12): e52013.

- Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One. 2012 ;7(12): e52013.

- Lee GH, Lee HY, Choi MK, Chung HW, Kim SW, Chae HJ. Protective effect of Curcuma longa L. extract on CCl(4)-induced acute hepatic stress. BMC Res Notes.2017 Feb 1;10(1):77.

- Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomed Pharmacother. 2018 Mar; 99:411-421.

- Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res. 2018 Jun;32(6):985-995. doi: 10.1002/ptr.6054. Epub 2018 Feb 26. Review.

- Liu Z, Huang P, Law S, Tian H, Leung W, Xu C. Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects. Front Pharmacol. 2018 Nov 27; 9:1374.

- Hesari A, Azizian M, Sheikhi A, Nesaei A, Sanaei S, Mahinparvar N, Derakhshani M, Hedayt P, Ghasemi F, Mirzaei H. Chemopreventive and therapeutic potential of curcumin in esophageal cancer: Current and future status. Int J Cancer. 2019 Mar 15 ;144(6):1215-1226.

- Chen M, Du ZY, Zheng X, Li DL, Zhou RP, Zhang K. Use of curcumin in diagnosis,prevention, and treatment of Alzheimer's disease. Neural Regen Res. 2018 Apr ;13(4):742-752. doi: 10.4103/1673-5374.230303. Review.

- Momtazi-Borojeni AA, Abdollahi E, Nikfar B, Chaichian S, Ekhlasi-Hundrieser M.Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy. Heart Fail Rev. 2019 May;24(3):399-409.

- Sanei M, Saberi-Demneh A. Effect of curcumin on memory impairment: A systematic review. Phytomedicine. 2019 Jan; 52:98-106.

- Pluta R, Ułamek-Kozioł M, Czuczwar SJ. Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer's Disease Phenotype. Int J Mol Sci. 2018 Dec 12 ;19(12). pii: E4002. doi: 10.3390/ijms19124002. Review.   

Protection cancer (sein, colon, estomac, foie...)

- Song X, Zhang M, Dai E, Luo Y. Molecular targets of curcumin in breast cancer (Review). Mol Med Rep. 2019 Jan;19(1):23-29.

- He G, Feng C, Vinothkumar R, Chen W, Dai X, Chen X, Ye Q, Qiu C, Zhou H, Wang Y, Liang G, Xie Y, Wu W. Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells. Cancer Chemother Pharmacol. 2016 Dec;78(6):1151-1161.

- Panahi Y, Darvishi B, Ghanei M, Jowzi N, Beiraghdar F, Varnamkhasti BS. Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway. Cytokine Growth Factor Rev. 2016 Apr; 28:21-9.

- He Y, Li W, Hu G, Sun H, Kong Q. Bioactivities of EF24, a Novel Curcumin Analog: A Review. Front Oncol. 2018 Dec 11 ;8 :614. doi :10.3389/fonc .2018. 00614.eCollection 2018. Review.

- Willenbacher E, Khan SZ, Mujica SCA, Trapani D, Hussain S, Wolf D, Willenbacher W, Spizzo G, Seeber A. Curcumin: New Insights into an Ancient Ingredient against Cancer. Int J Mol Sci. 2019 Apr 12;20(8).

- Bulku E, Stohs SJ, Cicero L, Brooks T, Halley H, Ray SD. Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Curr Neurovasc Res. 2012 Feb ;9(1):58-71.

- Tomeh MA, Hadianamrei R, Zhao X. A Review of Curcumin and Its Derivatives as Anticancer Agents. Int J Mol Sci. 2019 Feb 27;20(5). pii: E1033.

- Naeini MB, Momtazi AA, Jaafari MR, Johnston TP, Barreto G, Banach M, Sahebkar A. Antitumor effects of curcumin: A lipid perspective. J Cell Physiol. 2019 Feb 11.

- Hassanalilou T, Ghavamzadeh S, Khalili L. Curcumin and Gastric Cancer: a Review on Mechanisms of Action. J Gastrointest Cancer. 2019 Feb 6.

- Kouhpeikar H, Butler AE, Bamian F, Barreto GE, Majeed M, Sahebkar A. Curcumin as a therapeutic agent in leukemia. J Cell Physiol. 2019 Aug ;234(8):12404-12414. doi: 10.1002/jcp.28072. Epub 2019 Jan 4. Review 

- Talib WH, Al-Hadid SA, Ali MBW, Al-Yasari IH, Ali MRA. Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action. Breast Cancer (Dove Med Press). 2018 Nov 29; 10:207-217. doi: 10.2147/BCTT.S167812.eCollection 2018. Review.

- Hesari A, Azizian M, Sheikhi A, Nesaei A, Sanaei S, Mahinparvar N, Derakhshani M, Hedayt P, Ghasemi F, Mirzaei H. Chemopreventive and therapeutic potential of curcumin in esophageal cancer: Current and future status. Int J Cancer. 2019 Mar 15;144(6):1215-1226.

- Farhood B, Mortezaee K, Goradel NH, Khanlarkhani N, Salehi E, Nashtaei MS, Najafi M, Sahebkar A. Curcumin as an anti-inflammatory agent: Implications toradiotherapy and chemotherapy. J Cell Physiol. 2019 May;234(5):5728-5740.

- Zendehdel E, Abdollahi E, Momtazi-Borojeni AA, Korani M, Alavizadeh SH, Sahebkar A. The molecular mechanisms of curcumin's inhibitory effects on cancer stem cells. J Cell Biochem. 2019 Apr;120(4):4739-4747.

- Bachmeier BE, Killian PH, Melchart D. The Role of Curcumin in Prevention and Management of Metastatic Disease. Int J Mol Sci. 2018 Jun 9;19(6). pii: E1716.doi: 10.3390/ijms19061716. Review.

- Doello K, Ortiz R, Alvarez PJ, Melguizo C, Cabeza L, Prados J. Latest in Vitro and in Vivo Assay, Clinical Trials and Patents in Cancer Treatment using Curcumin: A Literature Review. Nutr Cancer. 2018 May-Jun;70(4):569-578. doi:10.1080 /01635581. 2018.1464347. Epub 2018 Apr 30. Review.   

ANTHOCYANES

Inflammation, oxydation et glycation

- Blando F, Calabriso N, Berland H, Maiorano G, Gerardi C, Carluccio MA, Andersen ØM. Radical Scavenging and Anti-Inflammatory Activities of Representative Anthocyanin Groupings from Pigment-Rich Fruits and Vegetables. Int J Mol Sci. 2018 Jan 6;19(1).

- Vendrame S, Klimis-Zacas D. Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev. 2015 Jun;73(6):348-58.

- Duarte LJ, Chaves VC, Nascimento MVPDS, Calvete E, Li M, Ciraolo E, Ghigo A, Hirsch E, Simões CMO, Reginatto FH, Dalmarco EM. Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits. Food Chem. 2018 May 1; 247:56-65.

- Jeong JW, Lee WS, Shin SC, Kim GY, Choi BT, Choi YH. Anthocyanins downregulate lipopolysaccharide-induced inflammatory responses in BV2 microglial cells by suppressing the NF-κB and Akt/MAPKs signaling pathways. Int J Mol Sci. 2013 Jan 14;14(1):1502-15.

- Yoon BI, Bae WJ, Choi YS, Kim SJ, Ha US, Hong SH, Sohn DW, Kim SW. Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model. Chin J Integr Med. 2018 Aug;24(8):621 626.

- Wongwichai T, Teeyakasem P, Pruksakorn D, Kongtawelert P, Pothacharoen P. Anthocyanins and metabolites from purple rice inhibit IL-1β-induced matrix metalloproteinases expression in human articular chondrocytes through the NF-κB and ERK/MAPK pathway. Biomed Pharmacother. 2019 Apr; 112:108610.

- Speciale A, Saija A, Bashllari R, Molonia MS, Muscara C, Occhiuto C, Cimino F, Cristani M. Anthocyanins As Modulators of Cell Redox-Dependent Pathways in Non-Communicable Diseases. Curr Med Chem. 2018 Nov 11.

- Thoppil RJ, Bhatia D, Barnes KF, Haznagy-Radnai E, Hohmann J, Darvesh AS, Bishayee A. Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. Curr Cancer Drug Targets. 2012 Nov 1 ;12(9):1244-57.

- Morais CA, de Rosso VV, Estadella D, Pisani LP. Anthocyanins as inflammatory modulators and the role of the gut microbiota. J Nutr Biochem. 2016 Jul; 33:1-7. doi: 10.1016/j.jnutbio.2015.11.008. Epub 2015 Nov 26. Review.

- Fang S, Lin F, Qu D, Liang X, Wang L. Characterization of Purified Red Cabbage Anthocyanins: Improvement in HPLC Separation and Protective Effect against H₂O₂-Induced Oxidative Stress in HepG2 Cells. Molecules. 2018 Dec 31 ;24(1).

- Farzaei MH, El-Senduny FF, Momtaz S, Parvizi F, Iranpanah A, Tewari D, Naseri R, Abdolghaffari AH, Rezaei N. An update on dietary consideration in inflammatory bowel disease: anthocyanins and more. Expert Rev Gastroenterol Hepatol. 2018 Oct;12(10):1007-1024.

- Szymanowska U, Baraniak B, Bogucka-Kocka A. Antioxidant, Anti-Inflammatory, and Postulated Cytotoxic Activity of Phenolic and Anthocyanin-Rich Fractions from Polana Raspberry (Rubus idaeus L.) Fruit and Juice-In Vitro Study. Molecules. 2018 Jul 21;23(7).

-Fernández J, García L, Monte J, Villar CJ, Lombó F. Functional Anthocyanin-Rich Sausages Diminish Colorectal Cancer in an Animal Model and Reduce Pro-Inflammatory Bacteria in the Intestinal Microbiota. Genes (Basel). 2018 Mar 1;9(3).

- da Costa GF, Santos IB, de Bem GF, Cordeiro VSC, da Costa CA, de Carvalho LCRM, Ognibene DT, Resende AC, de Moura RS. The Beneficial Effect of Anthocyanidin-Rich Vitis vinifera L. Grape Skin Extract on Metabolic Changes Induced by High-Fat Diet in Mice Involves Antiinflammatory and Antioxidant Actions. Phytother Res. 2017 Oct;31(10):1621-1632.

- Zhang H, Hassan YI, Renaud J, Liu R, Yang C, Sun Y, Tsao R. Bioaccessibility, bioavailability, and anti-inflammatory effects of anthocyanins from purple root vegetables using mono- and co-culture cell models. Mol Nutr Food Res. 2017 Oct;61(10).

- Ma H, Johnson SL, Liu W, DaSilva NA, Meschwitz S, Dain JA, Seeram NP. Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects. Int J Mol Sci. 2018 Feb 3;19(2).

- Suantawee T, Cheng H, Adisakwattana S. Protective effect of cyanidin against glucose- and methylglyoxal-induced protein glycation and oxidative DNA damage. Int J Biol Macromol. 2016 Dec;93(Pt A):814-821.

- Thilavech T, Abeywardena MY, Adams M, Dallimore J, Adisakwattana S. Naturally occurring anthocyanin cyanidin-3-rutinoside possesses inherent vasorelaxant actions and prevents methylglyoxal-induced vascular dysfunction in rat aorta and mesenteric arterial bed. Biomed Pharmacother. 2017 Nov; 95:1251-1259.

- Ganeko N, Kato N, Watanabe S, Bastian F, Miyake M, Ito H. Proanthocyanidin and anthocyanins from the hulls and beards of red-kerneled rice and their antiglycation properties. Biosci Biotechnol Biochem. 2019 Apr;83(4):605-608.

- Thilavech T, Ngamukote S, Belobrajdic D, Abeywardena M, Adisakwattana S. Cyanidin-3-rutinoside attenuates methylglyoxal-induced protein glycation and DNA damage via carbonyl trapping ability and scavenging reactive oxygen species. BMC Complement Altern Med. 2016 May 23; 16:138.

- Harris CS, Cuerrier A, Lamont E, Haddad PS, Arnason JT, Bennett SA, Johns T. Investigating wild berries as a dietary approach to reducing the formation of advanced glycation end products: chemical correlates of in vitro antiglycation activity. Plant Foods Hum Nutr. 2014 Mar;69(1):71-7.  

Protection cardio vasculaire, cérébrale, rétine, diabète, surpoids, obésité...

- Kimble R, Keane KM, Lodge JK, Howatson G. Dietary intake of anthocyanins and risk of cardiovascular disease: A systematic review and meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2018 Oct 2:1-12.

- Gaiz AA, Mosawy S, Colson N, Singh I. Potential of Anthocyanin to Prevent Cardiovascular Disease in Diabetes. Altern Ther Health Med. 2018 May;24(3):40-47. Review.

- Krga I, Milenkovic D. Anthocyanins: From Sources and Bioavailability to Cardiovascular-Health Benefits and Molecular Mechanisms of Action. J Agric Food Chem. 2019 Feb 20;67(7):1771-1783.

- Naseri R, Farzaei F, Haratipour P, Nabavi SF, Habtemariam S, Farzaei MH, Khodarahmi R, Tewari D, Momtaz S. Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review. Front Pharmacol. 2018 Dec 4; 9:1310. doi: 10.3389/fphar.2018.01310. eCollection 2018. Review.

- Belwal T, Nabavi SF, Nabavi SM, Habtemariam S. Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine. Nutrients. 2017 Oct 12;9(10). pii: E1111. doi: 10.3390/nu9101111. Review.

- Yang L, Ling W, Yang Y, Chen Y, Tian Z, Du Z, Chen J, Xie Y, Liu Z, Yang L.Role of Purified Anthocyanins in Improving Cardiometabolic Risk Factors in Chinese Men and Women with Prediabetes or Early Untreated Diabetes-A Randomized Controlled Trial. Nutrients. 2017 Oct 10;9(10).

- Azzini E, Giacometti J, Russo GL. Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies. Oxid Med Cell Longev. 2017; 2017:2740364. doi:10.1155/2017/2740364. Epub 2017 Jul 13. Review.

- Jamar G, Estadella D, Pisani LP. Contribution of anthocyanin-rich foods in obesity control through gut microbiota interactions. Biofactors. 2017 Jul 8;43(4):507-516.

- Jiang X, Li X, Zhu C, Sun J, Tian L, Chen W, Bai W. The target cells of anthocyanins in metabolic syndrome. Crit Rev Food Sci Nutr. 2018 Jul 11:1-71.

- Aboonabi A, Singh I. Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox. Biomed Pharmacother. 2015 May; 72:30-6. 

- Strathearn KE, Yousef GG, Grace MH, Roy SL, Tambe MA, Ferruzzi MG, Wu QL, Simon JE, Lila MA, Rochet JC. Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease. Brain Res. 2014 Mar 25; 1555:60-77.

- Putta S, Yarla NS, Kumar K E, Lakkappa DB, Kamal MA, Scotti L, Scotti MT, Ashraf GM, Rao BSB, D SK, Reddy GV, Tarasov VV, Imandi SB, Aliev G. Preventive and Therapeutic Potentials of Anthocyanins in Diabetes and Associated Complications. Curr Med Chem. 2018 ;25(39):5347-5371.

- Nabavi SF, Habtemariam S, Daglia M, Shafighi N, Barber AJ, Nabavi SM. Anthocyanins as a potential therapy for diabetic retinopathy. Curr Med Chem. 2015 ;22(1):51-8. Review.

- Ooe E, Kuse Y, Yako T, Sogon T, Nakamura S, Hara H, Shimazawa M. Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line. Mol Vis. 2018 Sep 24; 24:621-632.

- Huang WY, Wu H, Li DJ, Song JF, Xiao YD, Liu CQ, Zhou JZ, Sui ZQ. Protective Effects of Blueberry Anthocyanins against H (2)O(2)-Induced Oxidative Injuries in Human Retinal Pigment Epithelial Cells. J Agric Food Chem. 2018 Feb 21;66(7):1638-1648.

- Song Y, Huang L, Yu J. Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling. J Neuroimmunol. 2016 Dec 15; 301:1-6.

- Yacout SM, Gaillard ER. The Anthocyanins, Oenin and Callistephin, Protect RPE Cells Against Oxidative Stress. Photochem Photobiol. 2017 Mar;93(2):590-599.

- Winter AN, Brenner MC, Punessen N, Snodgrass M, Byars C, Arora Y, Linseman DA. Comparison of the Neuroprotective and Anti-Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4-Hydroxybenzoic Acid. Oxid Med Cell Longev. 2017; 2017:6297080.

- Pan Z, Cui M, Dai G, Yuan T, Li Y, Ji T, Pan Y. Protective Effect of Anthocyanin on Neurovascular Unit in Cerebral Ischemia/Reperfusion Injury in Rats. Front Neurosci. 2018 Dec 11; 12:947.

- Khan MS, Ali T, Kim MW, Jo MH, Chung JI, Kim MO. Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice. Mol Neurobiol. 2019 Jan;56(1):671-687.

- Thompson K, Hosking H, Pederick W, Singh I, Santhakumar AB. The effect of anthocyanin supplementation in modulating platelet function in sedentary population: a randomised, double-blind, placebo-controlled, cross-over trial. Br J Nutr. 2017 Sep;118(5):368-374.

- Rehman SU, Shah SA, Ali T, Chung JI, Kim MO. Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats. Mol Neurobiol. 2017 Jan;54(1):255-271.

- Turrini E, Ferruzzi L, Fimognari C. Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance. Curr Drug Targets. 2017 ;18(6) :629-640

- Lee YM, Yoon Y, Yoon H, Park HM, Song S, Yeum KJ. Dietary Anthocyanins against Obesity and Inflammation. Nutrients. 2017 Oct 1;9(10).

- Meng L, Xin G, Li B, Li D, Sun X, Yan T, Li L, Shi L, Cao S, Meng X. Anthocyanins Extracted from Aronia melanocarpa Protect SH-SY5Y Cells against Amyloid-beta (1-42)

- Induced Apoptosis by Regulating Ca(2+) Homeostasis and Inhibiting Mitochondrial Dysfunction. J Agric Food Chem. 2018 Dec 12;66(49):12967-12977. 

Protection cancer (sein, estomac, col utérin, colon...)

- Lin BW, Gong CC, Song HF, Cui YY. Effects of anthocyanins on the prevention and treatment of cancer. Br J Pharmacol. 2017 Jun;174(11):1226-1243. doi: 10.1111/bph.13627. Epub 2016 Oct 25. Review.

- Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V. CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE). PLoS One. 2019 Apr 9;14(4)

- Eskra JN, Schlicht MJ, Bosland MC. Effects of Black Raspberries and Their Ellagic Acid and Anthocyanin Constituents on Taxane Chemotherapy of Castration-Resistant Prostate Cancer Cells. Sci Rep. 2019 Mar 13;9(1):4367.

- Yang D, Wang X, Yuan W, Chen Z. Intake of Anthocyanins and Gastric Cancer Risk: A Comprehensive Meta-Analysis on Cohort and Case-Control Studies. J Nutr Sci Vitaminol (Tokyo). 2019;65(1):72-81.

- Vishnu VR, Renjith RS, Mukherjee A, Anil SR, Sreekumar J, Jyothi AN. Comparative Study on the Chemical Structure and In Vitro Antiproliferative Activity of Anthocyanins in Purple Root Tubers and Leaves of Sweet Potato (Ipomoea batatas). J Agric Food Chem. 2019 Mar 6;67(9):2467-2475.

-Yue E, Tuguzbaeva G, Chen X, Qin Y, Li A, Sun X, Dong C, Liu Y, Yu Y, Zahra SM, Shan Q, Jiang Y, Du Z, Bai Y. Anthocyanin is involved in the activation of pyroptosis in oral squamous cell carcinoma. Phytomedicine. 2019 Mar 15; 56:286 294.

- Wang X, Yang DY, Yang LQ, Zhao WZ, Cai LY, Shi HP. Anthocyanin Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies. J Am Coll Nutr. 2018 Dec 27:1-8.

- Ma X, Ning S. Cyanidin-3-glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3/VEGF pathway. Phytother Res. 2019 Jan;33(1):81-89.

- Lippert E, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E. Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model. Digestion. 2017;95(4):275-280.

- Venancio VP, Cipriano PA, Kim H, Antunes LM, Talcott ST, Mertens-Talcott SU.Cocoplum (Chrysobalanus icaco L.) anthocyanins exert anti-inflammatory activity in human colon cancer and non-malignant colon cells. Food Funct. 2017 Jan 25;8(1):307-314.

- de Sousa Moraes LF, Sun X, Peluzio MDCG, Zhu MJ. Anthocyanins /anthocyanidins and colorectal cancer: What is behind the scenes? Crit Rev Food Sci Nutr. 2019;59(1):59-71.-Lee YK, Lee WS, Kim GS, Park OJ. Anthocyanins are novel AMPKα1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. Oncol Rep. 2010 Dec;24(6):1471-7.

- Zhang H, Guo J, Mao L, Li Q, Guo M, Mu T, Zhang Q, Bi X. Up-regulation of miR-24-1-5p is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins. Br J Nutr. 2018 Oct 30:1-25.

- Chen L, Jiang B, Zhong C, Guo J, Zhang L, Mu T, Zhang Q, Bi X. Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis. 2018 Mar 8;39(3):471-481.

ROMARIN

Oxydation, inflammation et glycation 

- Colica C, Di Renzo L, Aiello V, De Lorenzo A, Abenavoli L. Rosmarinic Acid as Potential Anti-Inflammatory Agent. Rev Recent Clin Trials. 2018 ; 13(4) :240-242.

- de Oliveira JR, Camargo SEA, de Oliveira LD. Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent. J Biomed Sci. 2019 Jan 9;26(1):5. doi: 10.1186/s12929-019-0499-8. Review.

- da Rosa JS, Facchin BM, Bastos J, Siqueira MA, Micke GA, Dalmarco EM, Pizzolatti MG, Fröde TS. Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy. Planta Med. 2013 Nov;79(17):1605-14.

- Ou J, Huang J, Zhao D, Du B, Wang M. Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats. Food Funct. 2018 Feb 21;9(2):851-860.

- Loussouarn M, Krieger-Liszkay A, Svilar L, Bily A, Birtić S, Havaux M. Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms. Plant Physiol. 2017 Nov;175(3):1381-1394.

- Yeo IJ, Park JH, Jang JS, Lee DY, Park JE, Choi YE, Joo JH, Song JK, Jeon HO, Hong JT. Inhibitory effect of Carnosol on UVB-induced inflammation via inhibitionof STAT3. Arch Pharm Res. 2019 Mar;42(3):274-283.

- Govindaraj J, Sorimuthu Pillai S. Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats. Mol Cell Biochem. 2015 Jun ;404(1-2) :143-59.

- Jiang K, Ma X, Guo S, Zhang T, Zhao G, Wu H, Wang X, Deng G. Anti-inflammatory Effects of Rosmarinic Acid in Lipopolysaccharide-Induced Mastitis in Mice.Inflammation. 2018 Mar;41(2):437-448.

- Ou J, Huang J, Wang M, Ou S. Effect of rosmarinic acid and carnosic acid on AGEs formation in vitro. Food Chem. 2017 Apr 15; 221:1057-1061.

- de Almeida Gonçalves G, de Sá-Nakanishi AB, Comar JF, Bracht L, Dias MI, Barros L, Peralta RM, Ferreira ICFR, Bracht A. Water soluble compounds of Rosmarinus officinalis L. improve the oxidative and inflammatory states of rats with adjuvant-induced arthritis. Food Funct. 2018 Apr 25 ;9(4) :2328-2340.

- Rahbardar MG, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects. Phytomedicine. 2018 Feb 1 ;40 :59-67.  

Protection cardio vasculaire, hépatique, neurologique, diabète, syndrome métabolique, articulation, rétine...

- Ferreira LG, Celotto AC, Capellini VK, Albuquerque AA, Nadai TR, Carvalho MT, Evora PR. Is rosmarinic acid underestimated as an experimental cardiovascular drug ? Acta Cir Bras. 2013;28 Suppl 1:83-7. Review.

- Nabavi SF, Tenore GC, Daglia M, Tundis R, Loizzo MR, Nabavi SM. The cellular protective effects of ros

Notre vieillissement est certes inéluctable, mais peut-on le freiner substantiellement ? S'il apparaît difficile au cours de sa vie d'échapper aux maladies dites de civilisation (diabète, obésité, cancers, maladies cardiovasculaires, etc.), peut-on s'en protéger efficacement ? La réponse est deux fois oui.

Car la science a identifié à la fois les processus biologiques dégénératifs en cause et les solutions naturelles les plus puissantes pour les contrôler. Un livre référence pour une approche holistique et écologique de la Santé.

• Broché: 162 pages
• Editeur : MARIE CLAIRE ÉDITIONS (16/03/2021)
• Langue : Français
• ISBN-13: 979-10-323-0578-2
• Dimensions du produit: 16,9 cm × 22,9 cm × 1,2 cm

SYLIMARINE

Oxydation, inflammation et glycation 

- Reina M, Martínez A. Is Silybin the Best Free Radical Scavenger Compound in Silymarin? J Phys Chem B. 2016 May 26; 120(20):4568-78.

- Arafa Keshk W, Zahran SM, Katary MA, Abd-Elaziz Ali D. Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer. Chem Biol Interact. 2017 Aug 1; 273:266-272.

- Serviddio G, Bellanti F, Stanca E, Lunetti P, Blonda M, Tamborra R, Siculella L, Vendemiale G, Capobianco L, Giudetti AM. Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliarycirrhosis. Free Radic Biol Med. 2014 Aug; 73:117-26.

- Feng B, Meng R, Huang B, Shen S, Bi Y, Zhu D. Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice. Free Radic Res. 2016;50(3):314-27.

- Shin S, Lee JA, Kim M, Kum H, Jung E, Park D. Anti-glycation activities of phenolic constituents from Silybum marianum (Milk Thistle) flower in vitro and on human explants. Molecules. 2015 Feb 19;20(3):3549-64.

- Neelofar K, Arif Z, Ahmad J, Alam K. Inhibitory effect of silibinin on Amadori-albumin in diabetes mellitus: A multi-spectroscopic and biochemical approach. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Feb 15 ;209 :217-222.

- Gabrielová E, Jabůrek M, Gažák R, et al. Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism. J Bioenerg Biomembr. 2010 ;42(6) :499‐509.

Activités hépatoprotectrices, cardioprotectrices, neuroprotectrices, anti-inflammatoires et anti-cancérogène. Cytoprotection contre les agents toxiques chimiques et biologiques

- Fanoudi S, Alavi MS, Karimi G, Hosseinzadeh H. Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol. 2018 Jul 22:1-15.

- Zaulet M, Kevorkian SEM, Dinescu S, Cotoraci C, Suciu M, Herman H, Buburuzan L, Badulescu L, Ardelean A, Hermenean A. Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver. Exp Ther Med. 2017 Mar;13(3):821-828.

- Milić N, Milosević N, Suvajdzić L, Zarkov M, Abenavoli L. New therapeutic potentials of milk thistle (Silybum marianum). Nat Prod Commun. 2013Dec ;8(12):1801-10. Review.

- de Souza Santos V, Peters B, Côco LZ, Alves GM, de Assis ALEM, Nogueira BV,Meyrelles SS, Porto ML, Vasquez EC, Campagnaro BP, Pereira TMC. Silymarin protects against radiocontrast-induced nephropathy in mice. Life Sci. 2019 Apr 29. pii: S0024-3205(19)30329-7.

- Kim S, Han J, Jeon M, You D, Lee J, Kim HJ, Bae S, Nam SJ, Lee JE. Silibinin inhibits triple negative breast cancer cell motility by suppressing TGF-β2 expression. Tumour Biol. 2016 Aug;37(8):11397-407.

- Amiri M, Motamedi P, Vakili L, Dehghani N, Kiani F, Taheri Z, Torkamaneh S,Nasri P, Nasri H. Beyond the liver protective efficacy of silymarin; bright renoprotective effect on diabetic kidney disease. J Nephropharmacol. 2014 Jul 1;3(2):25-26.

- Wu JP, Tsai CC, Yeh YL, Lin YM, Lin CC, Day CH, Shen CY, Padma VV, Pan LF, Huang CY. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evid Based Complement Alternat Med. 2015; 2015:603529. doi: 10.1155/2015/603529.Epub 2015 Aug 3. Retraction in: Evid Based Complement Alternat Med. 2017; 2017:2575273.

- Gillessen A, Herrmann WA, Kemper M, Morath H, Mann K. [Effect of silymarin on liver health and quality of life. Results of a non-interventional study]. MMW Fortschr Med. 2014 Dec 15;156 Suppl 4:120-6.

- Yaghmaei P, Azarfar K, Dezfulian M, Ebrahim-Habibi A. Silymarin effect onamyloid-β plaque accumulation and gene expression of APP in an Alzheimer's disease rat model. Daru. 2014 Jan 24;22(1):24.

- Fatehi D, Mohammadi M, Shekarchi B, Shabani A, Seify M, Rostamzadeh A. Radioprotective effects of Silymarin on the sperm parameters of NMRI mice irradiated with γ-rays. J Photochem Photobiol B. 2018 Jan; 178:489-495.

- Elyasi S, Hosseini S, Niazi Moghadam MR, Aledavood SA, Karimi G. Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Phytother Res.2016 Nov;30(11):1879-1885.

Syndrome métabolique et diabète

- Wat E, Wang Y, Chan K, Law HW, Koon CM, Lau KM, Leung PC, Yan C, Lau CBS. An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome. Phytomedicine. 2018 Mar 15; 42:112-125.

- Vahabzadeh M, Amiri N, Karimi G. Effects of silymarin on metabolic syndrome: a review. J Sci Food Agric. 2018 Oct;98(13):4816-4823. doi: 10.1002/jsfa.9115. Epub 2018 Jun 27. Review.

- Tajmohammadi A, Razavi BM, Hosseinzadeh H. Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review. Phytother Res. 2018 Oct;32(10):1933-1949. doi:10.1002/ptr.6153. Epub 2018 Jul 17. Review.

- Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother Res. 2006 Dec;20(12):1036-9.

- Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin)extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018 May 15; 44:39-44.

- Hadi A, Pourmasoumi M, Mohammadi H, Symonds M, Miraghajani M. The effects of silymarin supplementation on metabolic status and oxidative stress in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials. Complement Ther Med. 2018 Dec; 41:311-319.

BERBÉRINE

Inflammation, oxydation et glycation

- Li CL, Tan LH, Wang YF, Luo CD, Chen HB, Lu Q, Li YC, Yang XB, Chen JN, Liu YH, Xie JH, Su ZR. Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo. Phytomedicine. 2019 Jan; 52:272-283.

- Li X, He P, Hou Y, Chen S, Xiao Z, Zhan J, Luo D, Gu M, Lin D. Berberine inhibits the interleukin-1 beta-induced inflammatory response via MAPK downregulation in rat articular chondrocytes.

- Liang Y, Fan C, Yan X, Lu X, Jiang H, Di S, Ma Z, Feng Y, Zhang Z, Feng P, Feng X, Feng J, Jin F. Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis. Phytother Res. 2019 Jan;33(1):130-148.

- Eissa LA, Kenawy HI, El-Karef A, Elsherbiny NM, El-Mihi KA. Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats. Chem Biol Interact. 2018 Oct 1;294:91-100.

- Kassab RB, Vasicek O, Ciz M, Lojek A, Perecko T. The effects of berberine on reactive oxygen species production in human neutrophils and in cell-free assays. Interdiscip Toxicol. 2017 Oct;10(2):61-65.

- Bai M, Liu Y, Zhou F, Zhang Y, Zhu Q, Zhang L, Zhang Q, Wang S, Zhu K, Wang X,Zhou L. Berberine inhibits glucose oxidation and insulin secretion in rat islets.Endocr J. 2018 Apr 26;65(4):469-477.

- Hao M, Li SY, Sun CK, Jingyu-Xu, Lin Y, Liu KX, Wang L, Li CX, Zhou Q, Du JL, Li H. Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro. Eur J Pharmacol. 2011 Mar 11;654(3):320-5.

- Qiu YY, Tang LQ, Wei W. Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy.Mol Cell Endocrinol. 2017 Mar 5; 443:89-105.

- Mo C, Wang L, Zhang J, Numazawa S, Tang H, Tang X, Han X, Li J, Yang M, WangZ, Wei D, Xiao H. The crosstalk between Nrf2 and AMPK signal pathways isimportant for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice. Antioxid Redox Signal. 2014 Feb 1;20(4):574-88.

- Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, Chen Z, Shioda S, Guo Y. Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation. Aging Dis. 2017 Dec 1;8(6):760-777.

Protection maladies cardiovasculaires (HTA...) et métaboliques (diabète, hyperlipidémie, glycation...)

- Feng X, Sureda A, Jafari S, Memariani Z, Tewari D, Annunziata G, Barrea L,Hassan STS, Šmejkal K, Malaník M, Sychrová A, Barreca D, Ziberna L, Mahomoodally MF, Zengin G, Xu S, Nabavi SM, Shen AZ. Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics. Theranostics. 2019 Mar16;9(7):1923-1951. doi: 10.7150/thno.30787. eCollection 2019. Review.

- Liang Y, Xu X, Yin M, Zhang Y, Huang L, Chen R, Ni J. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J. 2019 Jan 28;66(1):51-63.

- Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J, Sun G. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus,hyperlipemia and hypertension. J Ethnopharmacol. 2015 Feb 23;161:69-81.

- Koppen LM, Whitaker A, Rosene A, Beckett RD. Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review. J Evid Based Complementary Altern Med. 2017 Oct;22(4):956-968.

- Dong H, Zhao Y, Zhao L, Lu F. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med.2013 Apr;79(6):437-46. doi: 10.1055/s-0032-1328321. Epub 2013 Mar 19. Review.

- Cicero AF, Baggioni A. Berberine and Its Role in Chronic Disease. Adv Exp Med Biol. 2016;928:27-45. Review.

- Caliceti C, Franco P, Spinozzi S, Roda A, Cicero AF. Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders. Curr Med Chem. 2016;23(14):1460-76. Review.

- Chang W, Chen L, Hatch GM. Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies. Biochem Cell Biol.2015 Oct;93(5):479-86. doi: 10.1139/bcb-2014-0107. Epub 2014 Dec 1. Review.

- Derosa G, Maffioli P, Cicero AF. Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials. Expert Opin Biol Ther. 2012 Aug;12(8):1113-24.

- Pirillo A, Catapano AL. Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies.

- Atherosclerosis. 2015 Dec;243(2):449-61. doi: 10.1016/j.atherosclerosis.2015.09.032. Epub 2015 Sep 30. Review.

- Memon MA, Khan RN, Riaz S, Ain QU, Ahmed M, Kumar N. Methylglyoxal and insulin resistance in berberine-treated type 2 diabetic patients. J Res Med Sci. 2018 Dec 28;23:110. doi: 10.4103/jrms.JRMS_1078_17. eCollection 2018. Erratum in: J Res Med Sci. 2019 Apr 02;24:28.

- Almani SA, Memon IA, Shaikh TZ, Khoharo HK, Ujjan I. Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus. Iran J Basic Med Sci. 2017 May;20(5):511-515.

- Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P. Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7777-85.

- Ma H, He K, Zhu J, Li X, Ye X. The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine. Fitoterapia. 2019 Apr;134:210-220.

- Shao YJ, Tao J, Yu BB, Meng D, Yang XL, Sun JP, Qiu YX, Zhang XY. Berberine-Promoted CXCR4 Expression Accelerates Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Persons with Prehypertension. Chin J Integr Med. 2018 Dec;24(12):897-904.

- Yu Y, Zhang M, Hu Y, Zhao Y, Teng F, Lv X, Li J, Zhang Y, Hatch GM, Chen L.Increased Bioavailable Berberine Protects Against Myocardial Ischemia Reperfusion Injury Through Attenuation of NFκB and JNK Signaling Pathways. Int Heart J. 2018 Nov 28;59(6):1378-1388.

- Poudel A, Zhou J, Mekala N, Welchko R, Rosca M, Li L. Berberine protects against cytokine-induced inflammation through multiple pathways inundifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol. 2019 Apr 26.

 Neuro protection (récupération post-AVC, pathologies neuro dégénératives…)

- Zhu J, Cao D, Guo C, Liu M, Tao Y, Zhou J, Wang F, Zhao Y, Wei J, Zhang Y, Fang W, Li Y. Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling. Cell Mol Neurobiol. 2019 Apr 24.

- Fan D, Liu L, Wu Z, Cao M. Combating neurodegenerative diseases with the plantalkaloid berberine: molecular mechanisms and therapeutic potential. CurrNeuropharmacol. 2018 Apr 19.

- Ahmed T, Gilani AU, Abdollahi M, Daglia M, Nabavi SF, Nabavi SM. Berberine and neurodegeneration: A review of literature. Pharmacol Rep. 2015 Oct;67(5): 970-9.doi: 10.1016/j.pharep.2015.03.002.

- Kulkarni SK, Dhir A. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res. 2010 Mar;24(3):317-24.

- Chu M, Chen X, Wang J, Guo L, Wang Q, Gao Z, Kang J, Zhang M, Feng J, Guo Q, Li B, Zhang C, Guo X, Chu Z, Wang Y. Polypharmacology of Berberine Based on Multi-Target Binding Motifs. Front Pharmacol. 2018 Jul 24;9:801.

- Chu M, Chen X, Wang J, Guo L, Wang Q, Gao Z, Kang J, Zhang M, Feng J, Guo Q,Li B, Zhang C, Guo X, Chu Z, Wang Y. Polypharmacology of Berberine Based on Multi-Target Binding Motifs. Front Pharmacol. 2018 Jul 24;9:801.

- Huang SX, Qiu G, Cheng FR, Pei Z, Yang Z, Deng XH, Zhu JH, Chen L, Chen CC, Lin WF, Liu Y, Liu Z, Zhu FQ. Berberine Protects Secondary Injury in Mice with Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory Modulation. Neurochem Res. 2018 Sep;43(9):1814-1825.-Wang J, Zhang Y. Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via Sirt1/p38 MAPK expression. Mol Med Rep. 2018 May;17(5):6881-6886.

-Yu Y, Zhao Y, Teng F, Li J, Guan Y, Xu J, Lv X, Guan F, Zhang M, Chen L. Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats. J Nutr Health Aging. 2018;22(6):710-717.

- Fan J, Zhang K, Jin Y, Li B, Gao S, Zhu J, Cui R. Pharmacological effects of berberine on mood disorders. J Cell Mol Med. 2019 Jan;23(1):21-28. doi: 10.1111/jcmm.13930. Epub 2018 Nov 18. Review.   

Protection cancer (sein, foie, côlon, LLA, pancréas...)

- Farooqi AA, Qureshi MZ, Khalid S, Attar R, Martinelli C, Sabitaliyevich UY,Nurmurzayevich SB, Taverna S, Poltronieri P, Xu B. Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy. Cancers (Basel). 2019 Apr 4;11(4). pii: E478. doi: 10.3390/cancers11040478. Review.

- Jabbarzadeh Kaboli P, Rahmat A, Ismail P, Ling KH. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer. Eur J Pharmacol. 2014 Oct 5; 740:584-95. doi: 10.1016/j.ejphar.2014.06.025. Epub 2014 Jun 26. Review.

- Wu K, Yang Q, Mu Y, Zhou L, Liu Y, Zhou Q, He B. Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. Int J Oncol. 2012 Jul;41(1):292-8. doi: 10.3892/ijo.2012.1423.

- Albring KF, Weidemüller J, Mittag S, Weiske J, Friedrich K, Geroni MC,Lombardi P, Huber O. Berberine acts as a natural inhibitor of Wnt/β-catenin signaling--identification of more active 13-arylalkyl derivatives. Biofactors.2013 Nov-Dec;39(6):652-62.

- Ortiz LM, Lombardi P, Tillhon M, Scovassi AI. Berberine, an epiphany againstcancer. Molecules. 2014 Aug 15;19(8):12349-67. doi: 10.3390/molecules190812349.Review. 

- Diogo CV, Machado NG, Barbosa IA, Serafim TL, Burgeiro A, Oliveira PJ. Berberine as a promising safe anti-cancer agent - is there a role for mitochondria? Curr Drug Targets. 2011 Jun;12(6):850-9. Review.

- Dai B, Ma Y, Yang T, Fan M, Yu R, Su Q, Wang H, Liu F, Yang C, Zhang Y. Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma.Phytother Res. 2019 Mar;33(3):745-755.

- Hu S, Chen CW, Chen ST, Tsui KH, Tang TK, Cheng HT, Hwang GS, Yu JW, Li YC,Wang PS, Wang SW. Inhibitory effect of berberine on interleukin-2 secretion from PHA-treated lymphocytic Jurkat cells. Int Immunopharmacol. 2019 Jan;66:267-273.

- Kim S, You D, Jeong Y, Yu J, Kim SW, Nam SJ, Lee JE. Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells. Phytomedicine. 2018 Nov 15;50:43-49.

- Abrams SL, Follo MY, Steelman LS, Lertpiriyapong K, Cocco L, Ratti S, Martelli AM, Candido S, Libra M, Murata RM, Rosalen PL, Montalto G, Cervello M, Gizak A,Rakus D, Mao W, Lombardi P, McCubrey JA. Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells. Adv Biol Regul. 2019 Jan;71:172-182.

- Zhao Y, Jing Z, Li Y, Mao W. Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis. Oncol Rep. 2016 Jul;36(1):567-72.

- Jabbarzadeh Kaboli P, Leong MP, Ismail P, Ling KH. Antitumor effects of berberine against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 breast cancer cells using molecular modelling and in vitro study. Pharmacol Rep. 2019 Feb;71(1):13-23.

-Yao Z, Wan Y, Li B, Zhai C, Yao F, Kang Y, Liu Q, Lin D. Berberine induces mitochondrial‑mediated apoptosis and protective autophagy in human malignant pleural mesothelioma NCI‑H2452 cells. Oncol Rep. 2018 Dec;40(6):3603-3610.

- Agnarelli A, Natali M, Garcia-Gil M, Pesi R, Tozzi MG, Ippolito C, Bernardini N, Vignali R, Batistoni R, Bianucci AM, Marracci S. Cell-specific pattern of berberine pleiotropic effects on different human cell lines. Sci Rep. 2018 Jul 13;8(1):10599.

- Li L, Wang X, Sharvan R, Gao J, Qu S. Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways. Biomed Pharmacother. 2017 Nov; 95:1225-1231.

Protection rétinienne, rénale et hépatique

- Li S, Gaur U, Chong CM, Lin S, Fang J, Zeng Z, Wang H, Zheng W. Berberine Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of AMPK. Int J Mol Sci. 2018 Jun 12;19(6).

- Kumaş M, Eşrefoğlu M, Karataş E, Duymaç N, Kanbay S, Ergün IS, Üyüklü M, Koçyiğit A. Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats. Nefrologia. 2019 Jan 31. pii: S0211-6995(19)30004-9.

- Hung TC, Jassey A, Liu CH, Lin CJ, Lin CC, Wong SH, Wang JY, Yen MH, Lin LT. Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein. Phytomedicine. 2019 Feb; 53:62-69.

- Sun H, Liu Q, Hu H, Jiang Y, Shao W, Wang Q, Jiang Z, Gu A. Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis. Cell Death Dis. 2018 Aug 1;9(8):824.

- Gholampour F, Keikha S. Berberine protects the liver and kidney against functional disorders and histological damages induced by ferrous sulfate. Iran J Basic Med Sci. 2018 May;21(5):476-482.

- Adil M, Kandhare AD, Dalvi G, Ghosh P, Venkata S, Raygude KS, Bodhankar SL.Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Ren Fail. 2016 Jul;38(6):996-1006.

- Lin Y, Sheng M, Ding Y, Zhang N, Song Y, Du H, Lu N, Yu W. Berberine protects renal tubular cells against hypoxia/reoxygenation injury via the Sirt1/p53pathway. J Nat Med. 2018 Jun;72(3):715-723.

- Ni WJ, Ding HH, Tang LQ. Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms. Eur J Pharmacol. 2015 Aug 5;760:103-12.

- Wu D, Wen W, Qi CL, Zhao RX, Lü JH, Zhong CY, Chen YY. Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin. Phytomedicine. 2012 Jun 15;19(8-9):712-8.

CURCUMINE

Inflammation, oxydation et glycation

- Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB, Rahimi M, Mobini M, Jafarnejad S, Vahedpoor Z, Asemi Z. The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019 Feb;33(2):253-262. doi: 10.1002/ptr.6226. Epub 2018 Nov 7. Review.

- Edwards RL, Luis PB, Varuzza PV, Joseph AI, Presley SH, Chaturvedi R,Schneider C. The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites. J Biol Chem. 2017 Dec 29;292(52):21243-21252.

- Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin inducesglutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid Redox Signal. 2005 Jan-Feb ;7(1-2):32-41.

- Joseph AI, Edwards RL, Luis PB, Presley SH, Porter NA, Schneider C. Stability and anti-inflammatory activity of the reduction resistant curcumin analog,2,6-dimethyl-curcumin. Org Biomol Chem. 2018 May 2;16(17):3273-3281.

- Kunwar A, Barik A, Sandur SK, Indira Priyadarsini K. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin. Free Radic Res. 2011 Aug;45(8):959-65.

- He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules. 2015 May 20 ;20(5): 9183-213.doi: 10.3390/molecules20059183. Review.

- Yuan J, Botchway BOA, Zhang Y, Tan X, Wang X, Liu X. Curcumin Can Improve Spinal Cord Injury by Inhibiting TGF-β-SOX9 Signaling Pathway. Cell Mol Neurobiol. 2019 Mar 26.

- Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.Int Immunopharmacol. 2012 Feb;12(2):368-77.

- Yamagishi SI, Matsui T, Ishibashi Y, Isami F, Abe Y, Sakaguchi T, Higashimoto Y. Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System. Curr Pharm Des. 2017;23(8):1135-1141.

- Alizadeh M, Kheirouri S. Curcumin against advanced glycation end products (AGEs) and AGEs-induced detrimental agents. Crit Rev Food Sci Nutr. 2017 Nov 29:1-9.

- Sun YP, Gu JF, Tan XB, Wang CF, Jia XB, Feng L, Liu JP. Curcumin inhibits advanced glycation end product-induced oxidative stress and inflammatory responses in endothelial cell damage via trapping methylglyoxal. Mol Med Rep.2016 Feb;13(2):1475-86.

- Sowndhar Rajan B, Manivasagam S, Dhanusu S, Chandrasekar N, Krishna K, Kalaiarasu LP, Babu AA, Vellaichamy E. Diet with high content of advanced glycation end products induces systemic inflammation and weight gain in experimental mice: Protective role of curcumin and gallic acid. Food Chem Toxicol. 2018 Apr; 114:237-245.

- Cheng K, Yang A, Hu X, Zhu D, Liu K. Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide Induced Acute Lung Injury in Neonatal Rat Model by Activating Peroxisome Proliferator-Activated Receptor γ (PPARγ) Pathway.Med Sci Monit. 2018 Feb 26; 24:1178-1184. 

- Wei Y, Gao J, Qin L, Xu Y, Shi H, Qu L, Liu Y, Xu T, Liu T. Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy. Exp Ther Med. 2017 Dec;14(6):6052-6058.

- Mofidi Najjar F, Taghavi F, Ghadari R, Sheibani N, Moosavi-Movahedi AA. Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin. Arch Biochem Biophys. 2017 Sep 15; 630:81-90.

- Tang Y, Chen A. Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling. Lab Invest. 2014 May;94(5):503-16.

- Yang Q, Wu S, Mao X, Wang W, Tai H. Inhibition effect of curcumin on TNF-α and MMP-13 expression induced by advanced glycation end products in chondrocytes. Pharmacology. 2013;91(1-2):77-85.

- Liu JP, Feng L, Zhu MM, Wang RS, Zhang MH, Hu SY, Jia XB, Wu JJ. The in vitro protective effects of curcumin and demethoxycurcumin in Curcuma longa extract on advanced glycation end products-induced mesangial cell apoptosis and oxidative stress. Planta Med. 2012 Nov;78(16):1757-60.

- Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013 Sep;57(9):1529-42. 

Protection cérébrale, hépatique, rénale, cardiaque, contre toxiques

- Wang XS, Zhang ZR, Zhang MM, Sun MX, Wang WW, Xie CL. Neuroprotective properties of curcumin in toxin-base animal models of Parkinson's disease: a systematic experiment literatures review. BMC Complement Altern Med. 2017 Aug 17;17(1):412.

 -Ramkumar M, Rajasankar S, Gobi VV, Dhanalakshmi C, Manivasagam T, Justin Thenmozhi A, Essa MM, Kalandar A, Chidambaram R. Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone inducedneurotoxicity in SH-SY 5Y Neuroblastoma cells. BMC Complement Altern Med. 2017 Apr 18;17(1):217.

- Nery-Flores SD, Mendoza-Magaña ML, Ramírez-Herrera MA, Ramírez-Vázquez JJ, Romero-Prado MMJ, Cortez-Álvarez CR, Ramírez-Mendoza AA. Curcumin Exerted Neuroprotection against Ozone-Induced Oxidative Damage and Decreased NF-κB

- Activation in Rat Hippocampus and Serum Levels of Inflammatory Cytokines. Oxid Med Cell Longev. 2018 Dec 30; 2018:9620684.

- Abrahams S, Haylett WL, Johnson G, Carr JA, Bardien S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress:A review. Neuroscience. 2019 Feb 28; 406:1-21.

- Krishnamoorthy A, Tavoosi N, Chan GKL, Liu J, Ren G, Cavigiolio G, Ryan RO.Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I. FEBS Open Bio. 2018 Jan 10;8(2):302-310.

- Benzer F, Kandemir FM, Kucukler S, Comaklı S, Caglayan C. Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: by modulating inflammatory cytokines, apoptosis, oxidative stress and oxidative DNA damage. Arch Physiol Biochem. 2018 Dec;124(5):448-457.

- Topcu-Tarladacalisir Y, Sapmaz-Metin M, Karaca T. Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis. Ren Fail. 2016 Nov;38(10):1741-1748.

- Benzer F, Kandemir FM, Ozkaraca M, Kucukler S, Caglayan C. Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogationof inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats. J Biochem Mol Toxicol. 2018 Feb;32(2).

- Shi LY, Zhang L, Li H, Liu TL, Lai JC, Wu ZB, Qin J. Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Pharmacol Rep. 2018 Oct;70(5):1040-1046.

- Shi LY, Zhang L, Li H, Liu TL, Lai JC, Wu ZB, Qin J. Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Pharmacol Rep. 2018 Oct;70(5):1040-1046.

- Bukhari SN, Jantan I. Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer’s Disease. Mini Rev Med Chem. 2015;15(13):1110-21. Review.

- Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One. 2012;7(12): e52013.

- Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One. 2012 ;7(12): e52013.

- Lee GH, Lee HY, Choi MK, Chung HW, Kim SW, Chae HJ. Protective effect of Curcuma longa L. extract on CCl(4)-induced acute hepatic stress. BMC Res Notes.2017 Feb 1;10(1):77.

- Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomed Pharmacother. 2018 Mar; 99:411-421.

- Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res. 2018 Jun;32(6):985-995. doi: 10.1002/ptr.6054. Epub 2018 Feb 26. Review.

- Liu Z, Huang P, Law S, Tian H, Leung W, Xu C. Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects. Front Pharmacol. 2018 Nov 27; 9:1374.

- Hesari A, Azizian M, Sheikhi A, Nesaei A, Sanaei S, Mahinparvar N, Derakhshani M, Hedayt P, Ghasemi F, Mirzaei H. Chemopreventive and therapeutic potential of curcumin in esophageal cancer: Current and future status. Int J Cancer. 2019 Mar 15 ;144(6):1215-1226.

- Chen M, Du ZY, Zheng X, Li DL, Zhou RP, Zhang K. Use of curcumin in diagnosis,prevention, and treatment of Alzheimer's disease. Neural Regen Res. 2018 Apr ;13(4):742-752. doi: 10.4103/1673-5374.230303. Review.

- Momtazi-Borojeni AA, Abdollahi E, Nikfar B, Chaichian S, Ekhlasi-Hundrieser M.Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy. Heart Fail Rev. 2019 May;24(3):399-409.

- Sanei M, Saberi-Demneh A. Effect of curcumin on memory impairment: A systematic review. Phytomedicine. 2019 Jan; 52:98-106.

- Pluta R, Ułamek-Kozioł M, Czuczwar SJ. Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer's Disease Phenotype. Int J Mol Sci. 2018 Dec 12 ;19(12). pii: E4002. doi: 10.3390/ijms19124002. Review.   

Protection cancer (sein, colon, estomac, foie...)

- Song X, Zhang M, Dai E, Luo Y. Molecular targets of curcumin in breast cancer (Review). Mol Med Rep. 2019 Jan;19(1):23-29.

- He G, Feng C, Vinothkumar R, Chen W, Dai X, Chen X, Ye Q, Qiu C, Zhou H, Wang Y, Liang G, Xie Y, Wu W. Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells. Cancer Chemother Pharmacol. 2016 Dec;78(6):1151-1161.

- Panahi Y, Darvishi B, Ghanei M, Jowzi N, Beiraghdar F, Varnamkhasti BS. Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway. Cytokine Growth Factor Rev. 2016 Apr; 28:21-9.

- He Y, Li W, Hu G, Sun H, Kong Q. Bioactivities of EF24, a Novel Curcumin Analog: A Review. Front Oncol. 2018 Dec 11 ;8 :614. doi :10.3389/fonc .2018. 00614.eCollection 2018. Review.

- Willenbacher E, Khan SZ, Mujica SCA, Trapani D, Hussain S, Wolf D, Willenbacher W, Spizzo G, Seeber A. Curcumin: New Insights into an Ancient Ingredient against Cancer. Int J Mol Sci. 2019 Apr 12;20(8).

- Bulku E, Stohs SJ, Cicero L, Brooks T, Halley H, Ray SD. Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Curr Neurovasc Res. 2012 Feb ;9(1):58-71.

- Tomeh MA, Hadianamrei R, Zhao X. A Review of Curcumin and Its Derivatives as Anticancer Agents. Int J Mol Sci. 2019 Feb 27;20(5). pii: E1033.

- Naeini MB, Momtazi AA, Jaafari MR, Johnston TP, Barreto G, Banach M, Sahebkar A. Antitumor effects of curcumin: A lipid perspective. J Cell Physiol. 2019 Feb 11.

- Hassanalilou T, Ghavamzadeh S, Khalili L. Curcumin and Gastric Cancer: a Review on Mechanisms of Action. J Gastrointest Cancer. 2019 Feb 6.

- Kouhpeikar H, Butler AE, Bamian F, Barreto GE, Majeed M, Sahebkar A. Curcumin as a therapeutic agent in leukemia. J Cell Physiol. 2019 Aug ;234(8):12404-12414. doi: 10.1002/jcp.28072. Epub 2019 Jan 4. Review 

- Talib WH, Al-Hadid SA, Ali MBW, Al-Yasari IH, Ali MRA. Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action. Breast Cancer (Dove Med Press). 2018 Nov 29; 10:207-217. doi: 10.2147/BCTT.S167812.eCollection 2018. Review.

- Hesari A, Azizian M, Sheikhi A, Nesaei A, Sanaei S, Mahinparvar N, Derakhshani M, Hedayt P, Ghasemi F, Mirzaei H. Chemopreventive and therapeutic potential of curcumin in esophageal cancer: Current and future status. Int J Cancer. 2019 Mar 15;144(6):1215-1226.

- Farhood B, Mortezaee K, Goradel NH, Khanlarkhani N, Salehi E, Nashtaei MS, Najafi M, Sahebkar A. Curcumin as an anti-inflammatory agent: Implications toradiotherapy and chemotherapy. J Cell Physiol. 2019 May;234(5):5728-5740.

- Zendehdel E, Abdollahi E, Momtazi-Borojeni AA, Korani M, Alavizadeh SH, Sahebkar A. The molecular mechanisms of curcumin's inhibitory effects on cancer stem cells. J Cell Biochem. 2019 Apr;120(4):4739-4747.

- Bachmeier BE, Killian PH, Melchart D. The Role of Curcumin in Prevention and Management of Metastatic Disease. Int J Mol Sci. 2018 Jun 9;19(6). pii: E1716.doi: 10.3390/ijms19061716. Review.

- Doello K, Ortiz R, Alvarez PJ, Melguizo C, Cabeza L, Prados J. Latest in Vitro and in Vivo Assay, Clinical Trials and Patents in Cancer Treatment using Curcumin: A Literature Review. Nutr Cancer. 2018 May-Jun;70(4):569-578. doi:10.1080 /01635581. 2018.1464347. Epub 2018 Apr 30. Review.   

ANTHOCYANES

Inflammation, oxydation et glycation

- Blando F, Calabriso N, Berland H, Maiorano G, Gerardi C, Carluccio MA, Andersen ØM. Radical Scavenging and Anti-Inflammatory Activities of Representative Anthocyanin Groupings from Pigment-Rich Fruits and Vegetables. Int J Mol Sci. 2018 Jan 6;19(1).

- Vendrame S, Klimis-Zacas D. Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev. 2015 Jun;73(6):348-58.

- Duarte LJ, Chaves VC, Nascimento MVPDS, Calvete E, Li M, Ciraolo E, Ghigo A, Hirsch E, Simões CMO, Reginatto FH, Dalmarco EM. Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits. Food Chem. 2018 May 1; 247:56-65.

- Jeong JW, Lee WS, Shin SC, Kim GY, Choi BT, Choi YH. Anthocyanins downregulate lipopolysaccharide-induced inflammatory responses in BV2 microglial cells by suppressing the NF-κB and Akt/MAPKs signaling pathways. Int J Mol Sci. 2013 Jan 14;14(1):1502-15.

- Yoon BI, Bae WJ, Choi YS, Kim SJ, Ha US, Hong SH, Sohn DW, Kim SW. Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model. Chin J Integr Med. 2018 Aug;24(8):621 626.

- Wongwichai T, Teeyakasem P, Pruksakorn D, Kongtawelert P, Pothacharoen P. Anthocyanins and metabolites from purple rice inhibit IL-1β-induced matrix metalloproteinases expression in human articular chondrocytes through the NF-κB and ERK/MAPK pathway. Biomed Pharmacother. 2019 Apr; 112:108610.

- Speciale A, Saija A, Bashllari R, Molonia MS, Muscara C, Occhiuto C, Cimino F, Cristani M. Anthocyanins As Modulators of Cell Redox-Dependent Pathways in Non-Communicable Diseases. Curr Med Chem. 2018 Nov 11.

- Thoppil RJ, Bhatia D, Barnes KF, Haznagy-Radnai E, Hohmann J, Darvesh AS, Bishayee A. Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. Curr Cancer Drug Targets. 2012 Nov 1 ;12(9):1244-57.

- Morais CA, de Rosso VV, Estadella D, Pisani LP. Anthocyanins as inflammatory modulators and the role of the gut microbiota. J Nutr Biochem. 2016 Jul; 33:1-7. doi: 10.1016/j.jnutbio.2015.11.008. Epub 2015 Nov 26. Review.

- Fang S, Lin F, Qu D, Liang X, Wang L. Characterization of Purified Red Cabbage Anthocyanins: Improvement in HPLC Separation and Protective Effect against H₂O₂-Induced Oxidative Stress in HepG2 Cells. Molecules. 2018 Dec 31 ;24(1).

- Farzaei MH, El-Senduny FF, Momtaz S, Parvizi F, Iranpanah A, Tewari D, Naseri R, Abdolghaffari AH, Rezaei N. An update on dietary consideration in inflammatory bowel disease: anthocyanins and more. Expert Rev Gastroenterol Hepatol. 2018 Oct;12(10):1007-1024.

- Szymanowska U, Baraniak B, Bogucka-Kocka A. Antioxidant, Anti-Inflammatory, and Postulated Cytotoxic Activity of Phenolic and Anthocyanin-Rich Fractions from Polana Raspberry (Rubus idaeus L.) Fruit and Juice-In Vitro Study. Molecules. 2018 Jul 21;23(7).

-Fernández J, García L, Monte J, Villar CJ, Lombó F. Functional Anthocyanin-Rich Sausages Diminish Colorectal Cancer in an Animal Model and Reduce Pro-Inflammatory Bacteria in the Intestinal Microbiota. Genes (Basel). 2018 Mar 1;9(3).

- da Costa GF, Santos IB, de Bem GF, Cordeiro VSC, da Costa CA, de Carvalho LCRM, Ognibene DT, Resende AC, de Moura RS. The Beneficial Effect of Anthocyanidin-Rich Vitis vinifera L. Grape Skin Extract on Metabolic Changes Induced by High-Fat Diet in Mice Involves Antiinflammatory and Antioxidant Actions. Phytother Res. 2017 Oct;31(10):1621-1632.

- Zhang H, Hassan YI, Renaud J, Liu R, Yang C, Sun Y, Tsao R. Bioaccessibility, bioavailability, and anti-inflammatory effects of anthocyanins from purple root vegetables using mono- and co-culture cell models. Mol Nutr Food Res. 2017 Oct;61(10).

- Ma H, Johnson SL, Liu W, DaSilva NA, Meschwitz S, Dain JA, Seeram NP. Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects. Int J Mol Sci. 2018 Feb 3;19(2).

- Suantawee T, Cheng H, Adisakwattana S. Protective effect of cyanidin against glucose- and methylglyoxal-induced protein glycation and oxidative DNA damage. Int J Biol Macromol. 2016 Dec;93(Pt A):814-821.

- Thilavech T, Abeywardena MY, Adams M, Dallimore J, Adisakwattana S. Naturally occurring anthocyanin cyanidin-3-rutinoside possesses inherent vasorelaxant actions and prevents methylglyoxal-induced vascular dysfunction in rat aorta and mesenteric arterial bed. Biomed Pharmacother. 2017 Nov; 95:1251-1259.

- Ganeko N, Kato N, Watanabe S, Bastian F, Miyake M, Ito H. Proanthocyanidin and anthocyanins from the hulls and beards of red-kerneled rice and their antiglycation properties. Biosci Biotechnol Biochem. 2019 Apr;83(4):605-608.

- Thilavech T, Ngamukote S, Belobrajdic D, Abeywardena M, Adisakwattana S. Cyanidin-3-rutinoside attenuates methylglyoxal-induced protein glycation and DNA damage via carbonyl trapping ability and scavenging reactive oxygen species. BMC Complement Altern Med. 2016 May 23; 16:138.

- Harris CS, Cuerrier A, Lamont E, Haddad PS, Arnason JT, Bennett SA, Johns T. Investigating wild berries as a dietary approach to reducing the formation of advanced glycation end products: chemical correlates of in vitro antiglycation activity. Plant Foods Hum Nutr. 2014 Mar;69(1):71-7.  

Protection cardio vasculaire, cérébrale, rétine, diabète, surpoids, obésité...

- Kimble R, Keane KM, Lodge JK, Howatson G. Dietary intake of anthocyanins and risk of cardiovascular disease: A systematic review and meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2018 Oct 2:1-12.

- Gaiz AA, Mosawy S, Colson N, Singh I. Potential of Anthocyanin to Prevent Cardiovascular Disease in Diabetes. Altern Ther Health Med. 2018 May;24(3):40-47. Review.

- Krga I, Milenkovic D. Anthocyanins: From Sources and Bioavailability to Cardiovascular-Health Benefits and Molecular Mechanisms of Action. J Agric Food Chem. 2019 Feb 20;67(7):1771-1783.

- Naseri R, Farzaei F, Haratipour P, Nabavi SF, Habtemariam S, Farzaei MH, Khodarahmi R, Tewari D, Momtaz S. Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review. Front Pharmacol. 2018 Dec 4; 9:1310. doi: 10.3389/fphar.2018.01310. eCollection 2018. Review.

- Belwal T, Nabavi SF, Nabavi SM, Habtemariam S. Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine. Nutrients. 2017 Oct 12;9(10). pii: E1111. doi: 10.3390/nu9101111. Review.

- Yang L, Ling W, Yang Y, Chen Y, Tian Z, Du Z, Chen J, Xie Y, Liu Z, Yang L.Role of Purified Anthocyanins in Improving Cardiometabolic Risk Factors in Chinese Men and Women with Prediabetes or Early Untreated Diabetes-A Randomized Controlled Trial. Nutrients. 2017 Oct 10;9(10).

- Azzini E, Giacometti J, Russo GL. Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies. Oxid Med Cell Longev. 2017; 2017:2740364. doi:10.1155/2017/2740364. Epub 2017 Jul 13. Review.

- Jamar G, Estadella D, Pisani LP. Contribution of anthocyanin-rich foods in obesity control through gut microbiota interactions. Biofactors. 2017 Jul 8;43(4):507-516.

- Jiang X, Li X, Zhu C, Sun J, Tian L, Chen W, Bai W. The target cells of anthocyanins in metabolic syndrome. Crit Rev Food Sci Nutr. 2018 Jul 11:1-71.

- Aboonabi A, Singh I. Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox. Biomed Pharmacother. 2015 May; 72:30-6. 

- Strathearn KE, Yousef GG, Grace MH, Roy SL, Tambe MA, Ferruzzi MG, Wu QL, Simon JE, Lila MA, Rochet JC. Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease. Brain Res. 2014 Mar 25; 1555:60-77.

- Putta S, Yarla NS, Kumar K E, Lakkappa DB, Kamal MA, Scotti L, Scotti MT, Ashraf GM, Rao BSB, D SK, Reddy GV, Tarasov VV, Imandi SB, Aliev G. Preventive and Therapeutic Potentials of Anthocyanins in Diabetes and Associated Complications. Curr Med Chem. 2018 ;25(39):5347-5371.

- Nabavi SF, Habtemariam S, Daglia M, Shafighi N, Barber AJ, Nabavi SM. Anthocyanins as a potential therapy for diabetic retinopathy. Curr Med Chem. 2015 ;22(1):51-8. Review.

- Ooe E, Kuse Y, Yako T, Sogon T, Nakamura S, Hara H, Shimazawa M. Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line. Mol Vis. 2018 Sep 24; 24:621-632.

- Huang WY, Wu H, Li DJ, Song JF, Xiao YD, Liu CQ, Zhou JZ, Sui ZQ. Protective Effects of Blueberry Anthocyanins against H (2)O(2)-Induced Oxidative Injuries in Human Retinal Pigment Epithelial Cells. J Agric Food Chem. 2018 Feb 21;66(7):1638-1648.

- Song Y, Huang L, Yu J. Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling. J Neuroimmunol. 2016 Dec 15; 301:1-6.

- Yacout SM, Gaillard ER. The Anthocyanins, Oenin and Callistephin, Protect RPE Cells Against Oxidative Stress. Photochem Photobiol. 2017 Mar;93(2):590-599.

- Winter AN, Brenner MC, Punessen N, Snodgrass M, Byars C, Arora Y, Linseman DA. Comparison of the Neuroprotective and Anti-Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4-Hydroxybenzoic Acid. Oxid Med Cell Longev. 2017; 2017:6297080.

- Pan Z, Cui M, Dai G, Yuan T, Li Y, Ji T, Pan Y. Protective Effect of Anthocyanin on Neurovascular Unit in Cerebral Ischemia/Reperfusion Injury in Rats. Front Neurosci. 2018 Dec 11; 12:947.

- Khan MS, Ali T, Kim MW, Jo MH, Chung JI, Kim MO. Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice. Mol Neurobiol. 2019 Jan;56(1):671-687.

- Thompson K, Hosking H, Pederick W, Singh I, Santhakumar AB. The effect of anthocyanin supplementation in modulating platelet function in sedentary population: a randomised, double-blind, placebo-controlled, cross-over trial. Br J Nutr. 2017 Sep;118(5):368-374.

- Rehman SU, Shah SA, Ali T, Chung JI, Kim MO. Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats. Mol Neurobiol. 2017 Jan;54(1):255-271.

- Turrini E, Ferruzzi L, Fimognari C. Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance. Curr Drug Targets. 2017 ;18(6) :629-640

- Lee YM, Yoon Y, Yoon H, Park HM, Song S, Yeum KJ. Dietary Anthocyanins against Obesity and Inflammation. Nutrients. 2017 Oct 1;9(10).

- Meng L, Xin G, Li B, Li D, Sun X, Yan T, Li L, Shi L, Cao S, Meng X. Anthocyanins Extracted from Aronia melanocarpa Protect SH-SY5Y Cells against Amyloid-beta (1-42)

- Induced Apoptosis by Regulating Ca(2+) Homeostasis and Inhibiting Mitochondrial Dysfunction. J Agric Food Chem. 2018 Dec 12;66(49):12967-12977. 

Protection cancer (sein, estomac, col utérin, colon...)

- Lin BW, Gong CC, Song HF, Cui YY. Effects of anthocyanins on the prevention and treatment of cancer. Br J Pharmacol. 2017 Jun;174(11):1226-1243. doi: 10.1111/bph.13627. Epub 2016 Oct 25. Review.

- Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V. CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE). PLoS One. 2019 Apr 9;14(4)

- Eskra JN, Schlicht MJ, Bosland MC. Effects of Black Raspberries and Their Ellagic Acid and Anthocyanin Constituents on Taxane Chemotherapy of Castration-Resistant Prostate Cancer Cells. Sci Rep. 2019 Mar 13;9(1):4367.

- Yang D, Wang X, Yuan W, Chen Z. Intake of Anthocyanins and Gastric Cancer Risk: A Comprehensive Meta-Analysis on Cohort and Case-Control Studies. J Nutr Sci Vitaminol (Tokyo). 2019;65(1):72-81.

- Vishnu VR, Renjith RS, Mukherjee A, Anil SR, Sreekumar J, Jyothi AN. Comparative Study on the Chemical Structure and In Vitro Antiproliferative Activity of Anthocyanins in Purple Root Tubers and Leaves of Sweet Potato (Ipomoea batatas). J Agric Food Chem. 2019 Mar 6;67(9):2467-2475.

-Yue E, Tuguzbaeva G, Chen X, Qin Y, Li A, Sun X, Dong C, Liu Y, Yu Y, Zahra SM, Shan Q, Jiang Y, Du Z, Bai Y. Anthocyanin is involved in the activation of pyroptosis in oral squamous cell carcinoma. Phytomedicine. 2019 Mar 15; 56:286 294.

- Wang X, Yang DY, Yang LQ, Zhao WZ, Cai LY, Shi HP. Anthocyanin Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies. J Am Coll Nutr. 2018 Dec 27:1-8.

- Ma X, Ning S. Cyanidin-3-glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3/VEGF pathway. Phytother Res. 2019 Jan;33(1):81-89.

- Lippert E, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E. Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model. Digestion. 2017;95(4):275-280.

- Venancio VP, Cipriano PA, Kim H, Antunes LM, Talcott ST, Mertens-Talcott SU.Cocoplum (Chrysobalanus icaco L.) anthocyanins exert anti-inflammatory activity in human colon cancer and non-malignant colon cells. Food Funct. 2017 Jan 25;8(1):307-314.

- de Sousa Moraes LF, Sun X, Peluzio MDCG, Zhu MJ. Anthocyanins /anthocyanidins and colorectal cancer: What is behind the scenes? Crit Rev Food Sci Nutr. 2019;59(1):59-71.-Lee YK, Lee WS, Kim GS, Park OJ. Anthocyanins are novel AMPKα1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. Oncol Rep. 2010 Dec;24(6):1471-7.

- Zhang H, Guo J, Mao L, Li Q, Guo M, Mu T, Zhang Q, Bi X. Up-regulation of miR-24-1-5p is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins. Br J Nutr. 2018 Oct 30:1-25.

- Chen L, Jiang B, Zhong C, Guo J, Zhang L, Mu T, Zhang Q, Bi X. Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis. 2018 Mar 8;39(3):471-481.

ROMARIN

Oxydation, inflammation et glycation 

- Colica C, Di Renzo L, Aiello V, De Lorenzo A, Abenavoli L. Rosmarinic Acid as Potential Anti-Inflammatory Agent. Rev Recent Clin Trials. 2018 ; 13(4) :240-242.

- de Oliveira JR, Camargo SEA, de Oliveira LD. Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent. J Biomed Sci. 2019 Jan 9;26(1):5. doi: 10.1186/s12929-019-0499-8. Review.

- da Rosa JS, Facchin BM, Bastos J, Siqueira MA, Micke GA, Dalmarco EM, Pizzolatti MG, Fröde TS. Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy. Planta Med. 2013 Nov;79(17):1605-14.

- Ou J, Huang J, Zhao D, Du B, Wang M. Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats. Food Funct. 2018 Feb 21;9(2):851-860.

- Loussouarn M, Krieger-Liszkay A, Svilar L, Bily A, Birtić S, Havaux M. Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms. Plant Physiol. 2017 Nov;175(3):1381-1394.

- Yeo IJ, Park JH, Jang JS, Lee DY, Park JE, Choi YE, Joo JH, Song JK, Jeon HO, Hong JT. Inhibitory effect of Carnosol on UVB-induced inflammation via inhibitionof STAT3. Arch Pharm Res. 2019 Mar;42(3):274-283.

- Govindaraj J, Sorimuthu Pillai S. Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats. Mol Cell Biochem. 2015 Jun ;404(1-2) :143-59.

- Jiang K, Ma X, Guo S, Zhang T, Zhao G, Wu H, Wang X, Deng G. Anti-inflammatory Effects of Rosmarinic Acid in Lipopolysaccharide-Induced Mastitis in Mice.Inflammation. 2018 Mar;41(2):437-448.

- Ou J, Huang J, Wang M, Ou S. Effect of rosmarinic acid and carnosic acid on AGEs formation in vitro. Food Chem. 2017 Apr 15; 221:1057-1061.

- de Almeida Gonçalves G, de Sá-Nakanishi AB, Comar JF, Bracht L, Dias MI, Barros L, Peralta RM, Ferreira ICFR, Bracht A. Water soluble compounds of Rosmarinus officinalis L. improve the oxidative and inflammatory states of rats with adjuvant-induced arthritis. Food Funct. 2018 Apr 25 ;9(4) :2328-2340.

- Rahbardar MG, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects. Phytomedicine. 2018 Feb 1 ;40 :59-67.  

Protection cardio vasculaire, hépatique, neurologique, diabète, syndrome métabolique, articulation, rétine...

- Ferreira LG, Celotto AC, Capellini VK, Albuquerque AA, Nadai TR, Carvalho MT, Evora PR. Is rosmarinic acid underestimated as an experimental cardiovascular drug ? Acta Cir Bras. 2013;28 Suppl 1:83-7. Review.

- Nabavi SF, Tenore GC, Daglia M, Tundis R, Loizzo MR, Nabavi SM. The cellular protective effects of ros